Drug interactions
Aripiprazole + Fedratinib
Severity: Moderate
Aripiprazole and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and CYP2D6, the two main enzymes that clear aripiprazole. Aripiprazole exposure may rise, increasing the risk of akathisia, sedation, orthostatic hypotension and other dose-related adverse effects.
What this interaction means in plain words
Aripiprazole and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibition of CYP2D6 and CYP3A4 reduces aripiprazole metabolism.
What to do
Monitor for aripiprazole adverse effects and consider reducing the aripiprazole dose when starting fedratinib. Reassess the dose when fedratinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Aripiprazole with Fedratinib?
MediHelp rates the interaction as moderate. Aripiprazole and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 and CYP2D6, the two main enzymes that clear aripiprazole. Aripiprazole exposure may rise, increasing the risk of akathisia, sedation, orthostatic hypotension and other dose-related adverse effects.
How serious is the interaction between Aripiprazole and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for aripiprazole adverse effects and consider reducing the aripiprazole dose when starting fedratinib. Reassess the dose when fedratinib is stopped.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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