Drug interactions
Aripiprazole + Hydroxychloroquine
Severity: Moderate
Aripiprazole and Hydroxychloroquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have some QT-prolonging potential, though aripiprazole's effect is small. Together they may modestly add to arrhythmia risk in susceptible patients.
What this interaction means in plain words
Aripiprazole and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Hydroxychloroquine belongs to Musculoskeletal.
Why it happens
Possible additive QT prolongation; aripiprazole has weak effect on cardiac repolarization.
What to do
Check baseline ECG in patients with other risk factors and correct electrolytes. Monitor QTc if other QT-prolonging drugs are also used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Hydroxychloroquine?
MediHelp rates the interaction as moderate. Aripiprazole and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have some QT-prolonging potential, though aripiprazole's effect is small. Together they may modestly add to arrhythmia risk in susceptible patients.
How serious is the interaction between Aripiprazole and Hydroxychloroquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG in patients with other risk factors and correct electrolytes. Monitor QTc if other QT-prolonging drugs are also used.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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