Drug interactions
Aripiprazole + Idelalisib
Severity: Major
Aripiprazole and Idelalisib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib strongly inhibits CYP3A, one of the two main pathways that clear aripiprazole. Exposure to aripiprazole may increase considerably, raising the risk of akathisia, sedation, and other adverse effects.
What this interaction means in plain words
Aripiprazole and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Idelalisib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition by idelalisib reduces aripiprazole metabolism.
What to do
Reduce the aripiprazole dose to about half of the usual dose while a strong CYP3A4 inhibitor is used, and monitor for adverse effects. Return to the usual dose after idelalisib is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Aripiprazole with Idelalisib?
MediHelp rates the interaction as major. Aripiprazole and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib strongly inhibits CYP3A, one of the two main pathways that clear aripiprazole. Exposure to aripiprazole may increase considerably, raising the risk of akathisia, sedation, and other adverse effects.
How serious is the interaction between Aripiprazole and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the aripiprazole dose to about half of the usual dose while a strong CYP3A4 inhibitor is used, and monitor for adverse effects. Return to the usual dose after idelalisib is stopped.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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