Drug interactions
Aripiprazole + Methamphetamine
Severity: Moderate
Aripiprazole and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole is a partial dopamine agonist that can modulate the effects of stimulants, and methamphetamine may worsen psychosis or agitation. Effects on sedation and alertness are variable. Methamphetamine is also a CYP2D6 substrate, and aripiprazole has little effect on its metabolism.
What this interaction means in plain words
Aripiprazole and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
Opposing or modulating pharmacodynamic effects at dopamine receptors; no established pharmacokinetic interaction.
What to do
Monitor mental status, agitation, sleep and cardiovascular parameters. Adjust doses according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Methamphetamine?
MediHelp rates the interaction as moderate. Aripiprazole and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole is a partial dopamine agonist that can modulate the effects of stimulants, and methamphetamine may worsen psychosis or agitation. Effects on sedation and alertness are variable. Methamphetamine is also a CYP2D6 substrate, and aripiprazole has little effect on its metabolism.
How serious is the interaction between Aripiprazole and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental status, agitation, sleep and cardiovascular parameters. Adjust doses according to clinical response.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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