Drug interactions
Aripiprazole + Midostaurin
Severity: Moderate
Aripiprazole and Midostaurin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midostaurin has been associated with QT prolongation, and aripiprazole may add a small effect. The combination increases the theoretical risk of ventricular arrhythmia.
What this interaction means in plain words
Aripiprazole and Midostaurin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Midostaurin belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and monitor it during treatment, correcting electrolyte abnormalities. Reassess the antipsychotic if QTc increases significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Midostaurin
Frequently asked questions
Can I take Aripiprazole with Midostaurin?
MediHelp rates the interaction as moderate. Aripiprazole and Midostaurin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midostaurin has been associated with QT prolongation, and aripiprazole may add a small effect. The combination increases the theoretical risk of ventricular arrhythmia.
How serious is the interaction between Aripiprazole and Midostaurin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during treatment, correcting electrolyte abnormalities. Reassess the antipsychotic if QTc increases significantly.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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