Drug interactions
Aripiprazole + Mirtazapine
Severity: Minor
Aripiprazole and Mirtazapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, and combined use may increase drowsiness and impair alertness. Each has a small potential to affect the QT interval, though the clinical risk is low at usual doses. The combination is common in practice for augmentation.
What this interaction means in plain words
Aripiprazole and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression and possible small additive QT effects.
What to do
Monitor for excess sedation and counsel on driving. Obtain an ECG only if other QT risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Mirtazapine?
MediHelp rates the interaction as minor. Aripiprazole and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause sedation, and combined use may increase drowsiness and impair alertness. Each has a small potential to affect the QT interval, though the clinical risk is low at usual doses. The combination is common in practice for augmentation.
How serious is the interaction between Aripiprazole and Mirtazapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and counsel on driving. Obtain an ECG only if other QT risk factors are present.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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