Drug interactions
Aripiprazole + Modafinil
Severity: Minor
Aripiprazole and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil's wake-promoting effects may counter aripiprazole sedation, but modafinil can also cause agitation, anxiety or insomnia and may worsen psychosis. Modafinil weakly induces CYP3A4, which could modestly lower aripiprazole exposure.
What this interaction means in plain words
Aripiprazole and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Opposing CNS effects and possible weak CYP3A4 induction by modafinil.
What to do
Monitor psychiatric symptoms and aripiprazole response, adjusting dose if effect declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Modafinil?
MediHelp rates the interaction as minor. Aripiprazole and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil's wake-promoting effects may counter aripiprazole sedation, but modafinil can also cause agitation, anxiety or insomnia and may worsen psychosis. Modafinil weakly induces CYP3A4, which could modestly lower aripiprazole exposure.
How serious is the interaction between Aripiprazole and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric symptoms and aripiprazole response, adjusting dose if effect declines.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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