Drug interactions
Aripiprazole + Nevirapine
Severity: Moderate
Aripiprazole and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce aripiprazole exposure and cause loss of antipsychotic control. Relapse is a concern in patients who are stable.
What this interaction means in plain words
Aripiprazole and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, a major pathway of aripiprazole metabolism alongside CYP2D6.
What to do
Monitor psychiatric symptoms. Labeling advises doubling the aripiprazole dose with strong CYP3A4 inducers, and the dose should be reduced after the inducer is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Nevirapine?
MediHelp rates the interaction as moderate. Aripiprazole and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce aripiprazole exposure and cause loss of antipsychotic control. Relapse is a concern in patients who are stable.
How serious is the interaction between Aripiprazole and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric symptoms. Labeling advises doubling the aripiprazole dose with strong CYP3A4 inducers, and the dose should be reduced after the inducer is stopped.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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