Drug interactions
Aripiprazole + Risperidone
Severity: Moderate
Aripiprazole and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two antipsychotics adds dopamine-blocking and sedative effects, raising the risk of extrapyramidal symptoms, sedation, QT effects and rarely neuroleptic malignant syndrome. Aripiprazole may also be added to risperidone to reduce hyperprolactinemia, but the combination needs monitoring.
What this interaction means in plain words
Aripiprazole and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive D2 receptor antagonism or partial agonism and additive sedative and mild QT effects; aripiprazole may also weakly inhibit CYP2D6.
What to do
Use the lowest effective doses and monitor for movement disorders, sedation, and QTc in patients with risk factors. Review the need for combined antipsychotic therapy regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Aripiprazole with Risperidone?
MediHelp rates the interaction as moderate. Aripiprazole and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two antipsychotics adds dopamine-blocking and sedative effects, raising the risk of extrapyramidal symptoms, sedation, QT effects and rarely neuroleptic malignant syndrome. Aripiprazole may also be added to risperidone to reduce hyperprolactinemia, but the combination needs monitoring.
How serious is the interaction between Aripiprazole and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for movement disorders, sedation, and QTc in patients with risk factors. Review the need for combined antipsychotic therapy regularly.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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