Drug interactions
Bosentan + Rucaparib
Severity: Moderate
Bosentan and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP2C9 and may raise bosentan concentrations, raising the risk of bosentan adverse effects such as liver enzyme elevation, edema, and anemia.
What this interaction means in plain words
Bosentan and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP2C9, reducing bosentan metabolism.
What to do
Monitor liver function tests and for signs of bosentan toxicity during coadministration. Consider reducing the bosentan dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Bosentan with Rucaparib?
MediHelp rates the interaction as moderate. Bosentan and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib inhibits CYP2C9 and may raise bosentan concentrations, raising the risk of bosentan adverse effects such as liver enzyme elevation, edema, and anemia.
How serious is the interaction between Bosentan and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and for signs of bosentan toxicity during coadministration. Consider reducing the bosentan dose if adverse effects occur.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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