Drug interactions
Aripiprazole + Sotalol
Severity: Moderate
Aripiprazole and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole has a low QT liability, but sotalol markedly prolongs QT, so the combination may add some risk of ventricular arrhythmia. The additional effect is probably small compared with other antipsychotics.
What this interaction means in plain words
Aripiprazole and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Sotalol belongs to Cardiovascular.
Why it happens
Possible additive QT prolongation; aripiprazole's effect is weak.
What to do
Check baseline ECG and electrolytes and repeat after dose changes. Reassess if QTc rises substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Sotalol?
MediHelp rates the interaction as moderate. Aripiprazole and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole has a low QT liability, but sotalol markedly prolongs QT, so the combination may add some risk of ventricular arrhythmia. The additional effect is probably small compared with other antipsychotics.
How serious is the interaction between Aripiprazole and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and repeat after dose changes. Reassess if QTc rises substantially.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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