Drug interactions
Aripiprazole + Trazodone
Severity: Moderate
Aripiprazole and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have some potential to prolong the QT interval, though aripiprazole has a low liability. Combined use may add modestly to arrhythmia risk, mainly in patients with other risk factors.
What this interaction means in plain words
Aripiprazole and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization; trazodone may also modestly raise aripiprazole exposure via CYP2D6/3A4 effects.
What to do
Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium disturbances. Monitor QTc if doses are increased or other QT-prolonging drugs are added.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Trazodone?
MediHelp rates the interaction as moderate. Aripiprazole and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have some potential to prolong the QT interval, though aripiprazole has a low liability. Combined use may add modestly to arrhythmia risk, mainly in patients with other risk factors.
How serious is the interaction between Aripiprazole and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium disturbances. Monitor QTc if doses are increased or other QT-prolonging drugs are added.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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