Drug interactions
Aripiprazole + Trimipramine
Severity: Moderate
Aripiprazole and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents may cause sedation and have some QT-prolonging potential, although aripiprazole has a low risk. Trimipramine may also modestly raise aripiprazole levels through CYP2D6 inhibition.
What this interaction means in plain words
Aripiprazole and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression and QT effects, plus possible CYP2D6 inhibition.
What to do
Monitor sedation, orthostatic blood pressure and, in patients with risk factors, the ECG. Reduce the aripiprazole dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Trimipramine?
MediHelp rates the interaction as moderate. Aripiprazole and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents may cause sedation and have some QT-prolonging potential, although aripiprazole has a low risk. Trimipramine may also modestly raise aripiprazole levels through CYP2D6 inhibition.
How serious is the interaction between Aripiprazole and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, orthostatic blood pressure and, in patients with risk factors, the ECG. Reduce the aripiprazole dose if adverse effects emerge.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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