Drug interactions
Aripiprazole + Valbenazine
Severity: Moderate
Aripiprazole and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine can prolong the QT interval at higher exposures, and aripiprazole may add a minor effect. Valbenazine is partly metabolized by CYP2D6 and CYP3A4, so factors raising exposure increase the risk.
What this interaction means in plain words
Aripiprazole and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation.
What to do
Consider ECG monitoring in patients with cardiac risk factors or on CYP2D6/3A4 inhibitors. Correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Aripiprazole with Valbenazine?
MediHelp rates the interaction as moderate. Aripiprazole and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine can prolong the QT interval at higher exposures, and aripiprazole may add a minor effect. Valbenazine is partly metabolized by CYP2D6 and CYP3A4, so factors raising exposure increase the risk.
How serious is the interaction between Aripiprazole and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider ECG monitoring in patients with cardiac risk factors or on CYP2D6/3A4 inhibitors. Correct electrolyte abnormalities.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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