Drug interactions
Armodafinil + Atazanavir
Severity: Moderate
Armodafinil and Atazanavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and may raise armodafinil levels, while armodafinil's induction may lower atazanavir levels, particularly when unboosted. Reduced atazanavir exposure could risk virologic failure.
What this interaction means in plain words
Armodafinil and Atazanavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Atazanavir belongs to Anti Virals.
Why it happens
Opposing CYP3A4 effects: atazanavir inhibits armodafinil metabolism and armodafinil induces atazanavir metabolism.
What to do
Monitor HIV viral load and armodafinil adverse effects; consider a boosted atazanavir regimen and adjust the armodafinil dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Armodafinil with Atazanavir?
MediHelp rates the interaction as moderate. Armodafinil and Atazanavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and may raise armodafinil levels, while armodafinil's induction may lower atazanavir levels, particularly when unboosted. Reduced atazanavir exposure could risk virologic failure.
How serious is the interaction between Armodafinil and Atazanavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and armodafinil adverse effects; consider a boosted atazanavir regimen and adjust the armodafinil dose if needed.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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