Drug interactions
Armodafinil + Azelastine-fluticasone
Severity: Minor
Armodafinil and Azelastine-fluticasone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine may cause drowsiness while armodafinil promotes wakefulness, so the effects could partly oppose each other. No meaningful clinical interaction is established and the net effect is unpredictable.
What this interaction means in plain words
Armodafinil and Azelastine-fluticasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Azelastine-fluticasone belongs to Respiratory.
Why it happens
Opposing pharmacodynamic effects on alertness; no established pharmacokinetic mechanism.
What to do
No dose change is needed. Patients should not rely on armodafinil to offset azelastine-related drowsiness when driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Azelastine-fluticasone?
MediHelp rates the interaction as minor. Armodafinil and Azelastine-fluticasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azelastine may cause drowsiness while armodafinil promotes wakefulness, so the effects could partly oppose each other. No meaningful clinical interaction is established and the net effect is unpredictable.
How serious is the interaction between Armodafinil and Azelastine-fluticasone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Patients should not rely on armodafinil to offset azelastine-related drowsiness when driving.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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