Drug interactions
Armodafinil + Bosentan
Severity: Minor
Armodafinil and Bosentan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil, a weak to moderate CYP3A4 inducer, may lower bosentan concentrations, which are themselves dependent on CYP3A4 and CYP2C9. A reduced effect on pulmonary arterial pressure is theoretically possible.
What this interaction means in plain words
Armodafinil and Bosentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Bosentan belongs to Miscellaneous.
Why it happens
CYP3A4 induction by armodafinil increases bosentan metabolism.
What to do
Monitor clinical response in pulmonary arterial hypertension and functional status; no empiric dose change is generally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Armodafinil and Bosentan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Armodafinil
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Armodafinil with Bosentan?
MediHelp rates the interaction as minor. Armodafinil and Bosentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil, a weak to moderate CYP3A4 inducer, may lower bosentan concentrations, which are themselves dependent on CYP3A4 and CYP2C9. A reduced effect on pulmonary arterial pressure is theoretically possible.
How serious is the interaction between Armodafinil and Bosentan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response in pulmonary arterial hypertension and functional status; no empiric dose change is generally needed.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
