Drug interactions
Armodafinil + Buspirone
Severity: Minor
Armodafinil and Buspirone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak inducer of CYP3A4 and may lower buspirone concentrations, which are heavily dependent on CYP3A4 metabolism. This can reduce the anxiolytic effect of buspirone.
What this interaction means in plain words
Armodafinil and Buspirone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Buspirone belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 by armodafinil increases first-pass and systemic metabolism of buspirone.
What to do
Monitor for loss of anxiolytic response and increase the buspirone dose if clinically needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Buspirone?
MediHelp rates the interaction as minor. Armodafinil and Buspirone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak inducer of CYP3A4 and may lower buspirone concentrations, which are heavily dependent on CYP3A4 metabolism. This can reduce the anxiolytic effect of buspirone.
How serious is the interaction between Armodafinil and Buspirone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of anxiolytic response and increase the buspirone dose if clinically needed.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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