Drug interactions
Armodafinil + Carbinoxamine
Severity: Minor
Armodafinil and Carbinoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating first-generation antihistamine, whereas armodafinil promotes wakefulness. Armodafinil may reduce drowsiness but not necessarily the psychomotor impairment. Anticholinergic effects remain unaffected.
What this interaction means in plain words
Armodafinil and Carbinoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Carbinoxamine belongs to Respiratory.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no pharmacokinetic interaction established.
What to do
Counsel patients not to rely on perceived alertness when driving. Monitor for reduced antihistamine tolerability or insomnia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Armodafinil and Carbinoxamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Armodafinil
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Armodafinil with Carbinoxamine?
MediHelp rates the interaction as minor. Armodafinil and Carbinoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbinoxamine is a sedating first-generation antihistamine, whereas armodafinil promotes wakefulness. Armodafinil may reduce drowsiness but not necessarily the psychomotor impairment. Anticholinergic effects remain unaffected.
How serious is the interaction between Armodafinil and Carbinoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients not to rely on perceived alertness when driving. Monitor for reduced antihistamine tolerability or insomnia.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
