Drug interactions
Armodafinil + Cilostazol
Severity: Moderate
Armodafinil and Cilostazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil weakly induces CYP3A4 and inhibits CYP2C19, two pathways involved in cilostazol metabolism. The net effect on cilostazol exposure is uncertain and probably modest, but increased exposure to active metabolites is possible.
What this interaction means in plain words
Armodafinil and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Cilostazol belongs to Cardiovascular.
Why it happens
Opposing effects on cilostazol clearance through CYP3A4 induction and CYP2C19 inhibition by armodafinil.
What to do
Monitor for cilostazol adverse effects such as headache, palpitations and tachycardia, and for loss of efficacy; reduce the cilostazol dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Cilostazol?
MediHelp rates the interaction as moderate. Armodafinil and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil weakly induces CYP3A4 and inhibits CYP2C19, two pathways involved in cilostazol metabolism. The net effect on cilostazol exposure is uncertain and probably modest, but increased exposure to active metabolites is possible.
How serious is the interaction between Armodafinil and Cilostazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cilostazol adverse effects such as headache, palpitations and tachycardia, and for loss of efficacy; reduce the cilostazol dose if adverse effects emerge.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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