Drug interactions
Armodafinil + Clopidogrel
Severity: Minor
Armodafinil and Clopidogrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak CYP3A4 inducer and a weak CYP2C19 inhibitor, which could shift clopidogrel activation in opposite directions. Net clinical effect is unlikely to be large.
What this interaction means in plain words
Armodafinil and Clopidogrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Clopidogrel belongs to Cardiovascular.
Why it happens
Weak CYP3A4 induction and weak CYP2C19 inhibition by armodafinil may alter formation of the active clopidogrel metabolite.
What to do
No routine adjustment is required; be aware of possible variable antiplatelet effect and monitor clinically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clopidogrel
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Clopidogrel?
MediHelp rates the interaction as minor. Armodafinil and Clopidogrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak CYP3A4 inducer and a weak CYP2C19 inhibitor, which could shift clopidogrel activation in opposite directions. Net clinical effect is unlikely to be large.
How serious is the interaction between Armodafinil and Clopidogrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; be aware of possible variable antiplatelet effect and monitor clinically.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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