Drug interactions
Armodafinil + Cyclizine
Severity: Minor
Armodafinil and Cyclizine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine and armodafinil promotes wakefulness. Their opposing effects may make the alertness outcome unpredictable and could weaken the response to either drug.
What this interaction means in plain words
Armodafinil and Cyclizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Cyclizine belongs to Respiratory.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no pharmacokinetic mechanism is established.
What to do
No routine adjustment; monitor alertness and adjust doses if sedation or reduced antiemetic benefit is noted.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Armodafinil with Cyclizine?
MediHelp rates the interaction as minor. Armodafinil and Cyclizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclizine is a sedating antihistamine and armodafinil promotes wakefulness. Their opposing effects may make the alertness outcome unpredictable and could weaken the response to either drug.
How serious is the interaction between Armodafinil and Cyclizine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor alertness and adjust doses if sedation or reduced antiemetic benefit is noted.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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