Drug interactions
Armodafinil + Doxepin
Severity: Minor
Armodafinil and Doxepin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is sedating while armodafinil promotes wakefulness, so the effects may partly offset. Doxepin is metabolized by CYP2C19 and CYP2D6, and armodafinil inhibits CYP2C19, which could modestly raise doxepin levels.
What this interaction means in plain words
Armodafinil and Doxepin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Doxepin belongs to Dermatology.
Why it happens
Opposing CNS effects, with possible CYP2C19 inhibition by armodafinil reducing doxepin clearance.
What to do
Monitor for anticholinergic effects, sedation and cardiac effects of doxepin. Lower the doxepin dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Armodafinil with Doxepin?
MediHelp rates the interaction as minor. Armodafinil and Doxepin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxepin is sedating while armodafinil promotes wakefulness, so the effects may partly offset. Doxepin is metabolized by CYP2C19 and CYP2D6, and armodafinil inhibits CYP2C19, which could modestly raise doxepin levels.
How serious is the interaction between Armodafinil and Doxepin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, sedation and cardiac effects of doxepin. Lower the doxepin dose if adverse effects occur.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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