Drug interactions
Armodafinil + Imatinib
Severity: Minor
Armodafinil and Imatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak inducer of CYP3A4 and could modestly lower imatinib exposure. The effect is expected to be small, and a meaningful loss of imatinib efficacy has not been well documented.
What this interaction means in plain words
Armodafinil and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Imatinib belongs to Oncology.
Why it happens
Weak induction of CYP3A4 by armodafinil may increase imatinib metabolism.
What to do
No routine dose change is needed. Watch for reduced response to imatinib if armodafinil is started or stopped in a patient on stable therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Armodafinil with Imatinib?
MediHelp rates the interaction as minor. Armodafinil and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak inducer of CYP3A4 and could modestly lower imatinib exposure. The effect is expected to be small, and a meaningful loss of imatinib efficacy has not been well documented.
How serious is the interaction between Armodafinil and Imatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for reduced response to imatinib if armodafinil is started or stopped in a patient on stable therapy.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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