Drug interactions
Armodafinil + Isavuconazonium
Severity: Moderate
Armodafinil and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is metabolized by CYP3A4, and strong inducers are contraindicated with it. Armodafinil is a weaker inducer, but it may still lower isavuconazole concentrations and risk treatment failure of a serious fungal infection.
What this interaction means in plain words
Armodafinil and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Isavuconazonium belongs to Anti Fungals.
Why it happens
CYP3A4 induction by armodafinil increases isavuconazole clearance.
What to do
Monitor clinical response and isavuconazole levels where available, and consider alternative therapy if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Armodafinil and Isavuconazonium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Armodafinil
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Armodafinil with Isavuconazonium?
MediHelp rates the interaction as moderate. Armodafinil and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is metabolized by CYP3A4, and strong inducers are contraindicated with it. Armodafinil is a weaker inducer, but it may still lower isavuconazole concentrations and risk treatment failure of a serious fungal infection.
How serious is the interaction between Armodafinil and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and isavuconazole levels where available, and consider alternative therapy if response is inadequate.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
