Drug interactions
Armodafinil + Lapatinib
Severity: Moderate
Armodafinil and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib is cleared mainly by CYP3A4, and armodafinil may lower its exposure as a weak inducer. This could reduce antitumor efficacy.
What this interaction means in plain words
Armodafinil and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Lapatinib belongs to Oncology.
Why it happens
Induction of CYP3A4 increases lapatinib clearance.
What to do
Monitor tumor response, and consider an alternative to armodafinil.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Armodafinil with Lapatinib?
MediHelp rates the interaction as moderate. Armodafinil and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib is cleared mainly by CYP3A4, and armodafinil may lower its exposure as a weak inducer. This could reduce antitumor efficacy.
How serious is the interaction between Armodafinil and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response, and consider an alternative to armodafinil.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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