Drug interactions
Armodafinil + Lemborexant
Severity: Moderate
Armodafinil and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant is cleared mainly by CYP3A4, and induction by armodafinil may reduce its levels and weaken its effect on insomnia. Labeling advises avoiding moderate and strong CYP3A inducers. The pairing is also pharmacodynamically opposed, since one promotes wakefulness and the other sleep.
What this interaction means in plain words
Armodafinil and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Lemborexant belongs to Central Nervous System.
Why it happens
Armodafinil induces CYP3A4, increasing the clearance of lemborexant.
What to do
Avoid the combination when possible. If both are needed, evaluate for reduced sleep benefit and separate dosing times appropriately.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Lemborexant
Frequently asked questions
Can I take Armodafinil with Lemborexant?
MediHelp rates the interaction as moderate. Armodafinil and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lemborexant is cleared mainly by CYP3A4, and induction by armodafinil may reduce its levels and weaken its effect on insomnia. Labeling advises avoiding moderate and strong CYP3A inducers. The pairing is also pharmacodynamically opposed, since one promotes wakefulness and the other sleep.
How serious is the interaction between Armodafinil and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible. If both are needed, evaluate for reduced sleep benefit and separate dosing times appropriately.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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