Drug interactions
Armodafinil + Leniolisib
Severity: Moderate
Armodafinil and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib is metabolized mainly by CYP3A4, so induction by armodafinil may lower its exposure and reduce efficacy in APDS. Labeling advises avoiding moderate and strong CYP3A inducers.
What this interaction means in plain words
Armodafinil and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Leniolisib belongs to Miscellaneous.
Why it happens
Armodafinil induces CYP3A4, increasing the metabolism of leniolisib.
What to do
Avoid concomitant use if possible; otherwise monitor lymphoproliferation and immunologic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Leniolisib
Frequently asked questions
Can I take Armodafinil with Leniolisib?
MediHelp rates the interaction as moderate. Armodafinil and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib is metabolized mainly by CYP3A4, so induction by armodafinil may lower its exposure and reduce efficacy in APDS. Labeling advises avoiding moderate and strong CYP3A inducers.
How serious is the interaction between Armodafinil and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use if possible; otherwise monitor lymphoproliferation and immunologic response.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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