Drug interactions
Armodafinil + Mexiletine
Severity: Minor
Armodafinil and Mexiletine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak CYP inducer and might slightly lower mexiletine concentrations. The effect is expected to be small and clinical evidence is lacking.
What this interaction means in plain words
Armodafinil and Mexiletine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Mexiletine belongs to Cardiovascular.
Why it happens
Weak induction of hepatic enzymes by armodafinil may increase mexiletine clearance.
What to do
No empiric adjustment is needed; monitor therapeutic response to mexiletine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Mexiletine?
MediHelp rates the interaction as minor. Armodafinil and Mexiletine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak CYP inducer and might slightly lower mexiletine concentrations. The effect is expected to be small and clinical evidence is lacking.
How serious is the interaction between Armodafinil and Mexiletine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric adjustment is needed; monitor therapeutic response to mexiletine.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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