Drug interactions
Armodafinil + Mitotane
Severity: Moderate
Armodafinil and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and armodafinil is metabolised partly by CYP3A4. Armodafinil concentrations may fall, causing reduced wakefulness-promoting effect, and the induction can persist for weeks after mitotane is stopped.
What this interaction means in plain words
Armodafinil and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Mitotane belongs to Oncology.
Why it happens
Mitotane induces CYP3A4, increasing the metabolic clearance of armodafinil.
What to do
Monitor for loss of efficacy and increase the armodafinil dose if needed. Reassess the dose when mitotane is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Armodafinil with Mitotane?
MediHelp rates the interaction as moderate. Armodafinil and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and armodafinil is metabolised partly by CYP3A4. Armodafinil concentrations may fall, causing reduced wakefulness-promoting effect, and the induction can persist for weeks after mitotane is stopped.
How serious is the interaction between Armodafinil and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy and increase the armodafinil dose if needed. Reassess the dose when mitotane is discontinued.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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