Drug interactions
Armodafinil + Naldemedine
Severity: Minor
Armodafinil and Naldemedine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naldemedine is metabolised mainly by CYP3A, and armodafinil is a weak to moderate CYP3A4 inducer. Exposure to naldemedine may fall, which could reduce its effect on opioid-induced constipation.
What this interaction means in plain words
Armodafinil and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Armodafinil induces CYP3A4, increasing naldemedine metabolism.
What to do
Monitor bowel function and the clinical response to naldemedine. Consider alternative laxative therapy if efficacy is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Armodafinil with Naldemedine?
MediHelp rates the interaction as minor. Armodafinil and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naldemedine is metabolised mainly by CYP3A, and armodafinil is a weak to moderate CYP3A4 inducer. Exposure to naldemedine may fall, which could reduce its effect on opioid-induced constipation.
How serious is the interaction between Armodafinil and Naldemedine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and the clinical response to naldemedine. Consider alternative laxative therapy if efficacy is lost.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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