Drug interactions
Armodafinil + Oxymorphone
Severity: Minor
Armodafinil and Oxymorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a wakefulness-promoting agent and may partly offset opioid sedation, but it does not reverse respiratory depression. Armodafinil is a weak inducer of CYP3A4, which could modestly lower exposure to some opioids, but oxymorphone is cleared mainly by glucuronidation so this is unlikely to matter.
What this interaction means in plain words
Armodafinil and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Opposing pharmacodynamic effects on alertness; pharmacokinetic effect on oxymorphone is probably negligible.
What to do
No dose adjustment is needed. Do not rely on armodafinil to mask sedation, and monitor analgesic response and respiratory status.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Oxymorphone?
MediHelp rates the interaction as minor. Armodafinil and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a wakefulness-promoting agent and may partly offset opioid sedation, but it does not reverse respiratory depression. Armodafinil is a weak inducer of CYP3A4, which could modestly lower exposure to some opioids, but oxymorphone is cleared mainly by glucuronidation so this is unlikely to matter.
How serious is the interaction between Armodafinil and Oxymorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Do not rely on armodafinil to mask sedation, and monitor analgesic response and respiratory status.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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