Drug interactions
Armodafinil + Paclitaxel
Severity: Minor
Armodafinil and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may weakly induce CYP3A4, which is one of the pathways that clear paclitaxel. Any reduction in paclitaxel exposure is expected to be small and its clinical significance is unclear.
What this interaction means in plain words
Armodafinil and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Paclitaxel belongs to Oncology.
Why it happens
Weak CYP3A4 induction by armodafinil may increase paclitaxel metabolism.
What to do
No empiric adjustment is needed. Follow the usual clinical and hematologic response to paclitaxel.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Paclitaxel
Frequently asked questions
Can I take Armodafinil with Paclitaxel?
MediHelp rates the interaction as minor. Armodafinil and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil may weakly induce CYP3A4, which is one of the pathways that clear paclitaxel. Any reduction in paclitaxel exposure is expected to be small and its clinical significance is unclear.
How serious is the interaction between Armodafinil and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric adjustment is needed. Follow the usual clinical and hematologic response to paclitaxel.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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