Drug interactions
Armodafinil + Procarbazine
Severity: Major
Armodafinil and Procarbazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has monoamine oxidase inhibitor activity, and combining it with a stimulant like armodafinil may cause excessive sympathetic stimulation and hypertensive reactions. Armodafinil labeling advises caution with MAO inhibitors.
What this interaction means in plain words
Armodafinil and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Armodafinil belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition by procarbazine combined with the CNS stimulant and pressor effects of armodafinil.
What to do
Avoid the combination where possible. If used, monitor blood pressure closely and educate the patient to report severe headache or palpitations.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Armodafinil and Procarbazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Armodafinil
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Armodafinil with Procarbazine?
MediHelp rates the interaction as major. Armodafinil and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procarbazine has monoamine oxidase inhibitor activity, and combining it with a stimulant like armodafinil may cause excessive sympathetic stimulation and hypertensive reactions. Armodafinil labeling advises caution with MAO inhibitors.
How serious is the interaction between Armodafinil and Procarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor blood pressure closely and educate the patient to report severe headache or palpitations.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
