Drug interactions
Armodafinil + Quetiapine
Severity: Moderate
Armodafinil and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may reduce quetiapine plasma levels by inducing CYP3A4, potentially lowering its antipsychotic or mood-stabilizing effect. Armodafinil also opposes quetiapine sedation and may aggravate psychiatric symptoms.
What this interaction means in plain words
Armodafinil and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
CYP3A4 induction by armodafinil reducing quetiapine exposure, plus opposing CNS effects.
What to do
Monitor psychiatric symptoms and quetiapine response, and increase the quetiapine dose if efficacy is lost. Review the need for armodafinil if symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Armodafinil with Quetiapine?
MediHelp rates the interaction as moderate. Armodafinil and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may reduce quetiapine plasma levels by inducing CYP3A4, potentially lowering its antipsychotic or mood-stabilizing effect. Armodafinil also opposes quetiapine sedation and may aggravate psychiatric symptoms.
How serious is the interaction between Armodafinil and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric symptoms and quetiapine response, and increase the quetiapine dose if efficacy is lost. Review the need for armodafinil if symptoms worsen.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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