Drug interactions
Armodafinil + Quinidine
Severity: Minor
Armodafinil and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak CYP3A4 inducer and may modestly lower quinidine exposure. Quinidine may in turn raise armodafinil levels via P-glycoprotein inhibition; the clinical effects are expected to be small.
What this interaction means in plain words
Armodafinil and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Quinidine belongs to Anti Parasitic.
Why it happens
Weak CYP3A4 induction by armodafinil and P-glycoprotein inhibition by quinidine.
What to do
No routine adjustment is needed. Monitor quinidine response and ECG if therapy is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Quinidine?
MediHelp rates the interaction as minor. Armodafinil and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak CYP3A4 inducer and may modestly lower quinidine exposure. Quinidine may in turn raise armodafinil levels via P-glycoprotein inhibition; the clinical effects are expected to be small.
How serious is the interaction between Armodafinil and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor quinidine response and ECG if therapy is started or stopped.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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