Drug interactions
Armodafinil + Ramelteon
Severity: Minor
Armodafinil and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may weakly induce CYP enzymes, potentially lowering ramelteon levels. The clinical significance is uncertain, and the drugs also have opposing effects on wakefulness.
What this interaction means in plain words
Armodafinil and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Ramelteon belongs to Central Nervous System.
Why it happens
Possible weak enzyme induction increasing ramelteon metabolism, with opposing pharmacodynamic effects.
What to do
Monitor sleep response to ramelteon and adjust therapy if efficacy appears reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Ramelteon?
MediHelp rates the interaction as minor. Armodafinil and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil may weakly induce CYP enzymes, potentially lowering ramelteon levels. The clinical significance is uncertain, and the drugs also have opposing effects on wakefulness.
How serious is the interaction between Armodafinil and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sleep response to ramelteon and adjust therapy if efficacy appears reduced.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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