Drug interactions
Armodafinil + Ritonavir
Severity: Minor
Armodafinil and Ritonavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak CYP3A4 inducer and may slightly lower ritonavir exposure. The effect is likely small, but it could matter when ritonavir is used as a pharmacokinetic booster.
What this interaction means in plain words
Armodafinil and Ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Ritonavir belongs to Anti Virals.
Why it happens
Weak CYP3A4 induction by armodafinil increases ritonavir metabolism.
What to do
Monitor virologic response in patients on ritonavir-containing regimens. No empirical dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Armodafinil with Ritonavir?
MediHelp rates the interaction as minor. Armodafinil and Ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak CYP3A4 inducer and may slightly lower ritonavir exposure. The effect is likely small, but it could matter when ritonavir is used as a pharmacokinetic booster.
How serious is the interaction between Armodafinil and Ritonavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor virologic response in patients on ritonavir-containing regimens. No empirical dose change is usually needed.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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