Drug interactions
Armodafinil + Roflumilast
Severity: Minor
Armodafinil and Roflumilast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak CYP3A4 inducer and may modestly lower roflumilast and its active metabolite exposure. Any loss of efficacy is likely small.
What this interaction means in plain words
Armodafinil and Roflumilast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Roflumilast belongs to Respiratory.
Why it happens
Weak induction of CYP3A4 by armodafinil increases metabolism of roflumilast.
What to do
No dose adjustment is usually required; watch for reduced COPD control if the combination is long-term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Roflumilast
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Roflumilast?
MediHelp rates the interaction as minor. Armodafinil and Roflumilast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak CYP3A4 inducer and may modestly lower roflumilast and its active metabolite exposure. Any loss of efficacy is likely small.
How serious is the interaction between Armodafinil and Roflumilast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; watch for reduced COPD control if the combination is long-term.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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