Drug interactions
Armodafinil + Secobarbital
Severity: Moderate
Armodafinil and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a wakefulness-promoting agent and secobarbital is a sedative barbiturate, so their effects on alertness oppose one another. Secobarbital is also an enzyme inducer and may lower armodafinil exposure, reducing its wake-promoting effect.
What this interaction means in plain words
Armodafinil and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on arousal, plus barbiturate induction of CYP3A4 that may increase armodafinil clearance.
What to do
Monitor for reduced armodafinil efficacy and for unpredictable sedation or alertness. Increase armodafinil dose only if clinically needed and reassess when the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Secobarbital?
MediHelp rates the interaction as moderate. Armodafinil and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil is a wakefulness-promoting agent and secobarbital is a sedative barbiturate, so their effects on alertness oppose one another. Secobarbital is also an enzyme inducer and may lower armodafinil exposure, reducing its wake-promoting effect.
How serious is the interaction between Armodafinil and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced armodafinil efficacy and for unpredictable sedation or alertness. Increase armodafinil dose only if clinically needed and reassess when the barbiturate is stopped.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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