Drug interactions
Armodafinil + Sufentanil
Severity: Moderate
Armodafinil and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a potent opioid causing sedation and respiratory depression. Armodafinil may mask drowsiness but does not reverse respiratory depression, and weak CYP3A4 induction may modestly reduce sufentanil exposure.
What this interaction means in plain words
Armodafinil and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Opposing CNS effects plus weak CYP3A4 induction affecting sufentanil metabolism.
What to do
Monitor respiratory rate and analgesic response, and titrate sufentanil to effect. Do not treat alertness as evidence of safe opioid exposure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Armodafinil with Sufentanil?
MediHelp rates the interaction as moderate. Armodafinil and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is a potent opioid causing sedation and respiratory depression. Armodafinil may mask drowsiness but does not reverse respiratory depression, and weak CYP3A4 induction may modestly reduce sufentanil exposure.
How serious is the interaction between Armodafinil and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate and analgesic response, and titrate sufentanil to effect. Do not treat alertness as evidence of safe opioid exposure.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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