Drug interactions
Armodafinil + Thioridazine
Severity: Moderate
Armodafinil and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine is sedating and strongly QT-prolonging, while armodafinil is a stimulant that can raise heart rate and cause palpitations. The sedative and wake-promoting effects oppose each other unpredictably, and the cardiac effects of the combination warrant attention.
What this interaction means in plain words
Armodafinil and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Opposing CNS effects with potential additive cardiovascular effects; no established pharmacokinetic interaction.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes. Reassess the need for armodafinil if palpitations or arrhythmia occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Armodafinil with Thioridazine?
MediHelp rates the interaction as moderate. Armodafinil and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine is sedating and strongly QT-prolonging, while armodafinil is a stimulant that can raise heart rate and cause palpitations. The sedative and wake-promoting effects oppose each other unpredictably, and the cardiac effects of the combination warrant attention.
How serious is the interaction between Armodafinil and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes. Reassess the need for armodafinil if palpitations or arrhythmia occur.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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