Drug interactions
Armodafinil + Tivozanib
Severity: Minor
Armodafinil and Tivozanib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tivozanib is metabolised in part by CYP3A4, and armodafinil may lower its exposure through weak induction. This could reduce anticancer efficacy, though the effect is probably modest.
What this interaction means in plain words
Armodafinil and Tivozanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Tivozanib belongs to Oncology.
Why it happens
Weak CYP3A4 induction by armodafinil increases tivozanib clearance.
What to do
Monitor tumour response. Avoid strong CYP3A4 inducers; no empirical dose change is needed for armodafinil.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Tivozanib
- Amobarbital + Tivozanib Major
- Carbamazepine + Tivozanib Major
- Phenytoin + Tivozanib Major
- Secobarbital + Tivozanib Major
- Apalutamide + Tivozanib Moderate
- Bosentan + Tivozanib Moderate
Frequently asked questions
Can I take Armodafinil with Tivozanib?
MediHelp rates the interaction as minor. Armodafinil and Tivozanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tivozanib is metabolised in part by CYP3A4, and armodafinil may lower its exposure through weak induction. This could reduce anticancer efficacy, though the effect is probably modest.
How serious is the interaction between Armodafinil and Tivozanib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumour response. Avoid strong CYP3A4 inducers; no empirical dose change is needed for armodafinil.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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