Drug interactions
Armodafinil + Vardenafil
Severity: Minor
Armodafinil and Vardenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak CYP3A4 inducer and may slightly lower vardenafil exposure. A clinically meaningful loss of effect is uncommon.
What this interaction means in plain words
Armodafinil and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Vardenafil belongs to Genitourinary.
Why it happens
Weak induction of CYP3A4 increases vardenafil metabolism.
What to do
Monitor erectile response and increase vardenafil within labeled limits only if effect is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Vardenafil?
MediHelp rates the interaction as minor. Armodafinil and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak CYP3A4 inducer and may slightly lower vardenafil exposure. A clinically meaningful loss of effect is uncommon.
How serious is the interaction between Armodafinil and Vardenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor erectile response and increase vardenafil within labeled limits only if effect is inadequate.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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