Drug interactions
Armodafinil + Voxelotor
Severity: Moderate
Armodafinil and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may reduce voxelotor exposure by inducing CYP3A4, which could lower efficacy in sickle cell disease. Voxelotor itself may raise concentrations of sensitive CYP3A4 substrates, but the effect on armodafinil is less clear.
What this interaction means in plain words
Armodafinil and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Voxelotor belongs to Miscellaneous.
Why it happens
CYP3A4 induction by armodafinil increases voxelotor clearance, while voxelotor may inhibit CYP3A4.
What to do
Avoid the combination where possible. If it is unavoidable, increase the voxelotor dose per labeling and monitor hemoglobin response and armodafinil adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Armodafinil and Voxelotor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Armodafinil
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Armodafinil with Voxelotor?
MediHelp rates the interaction as moderate. Armodafinil and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may reduce voxelotor exposure by inducing CYP3A4, which could lower efficacy in sickle cell disease. Voxelotor itself may raise concentrations of sensitive CYP3A4 substrates, but the effect on armodafinil is less clear.
How serious is the interaction between Armodafinil and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is unavoidable, increase the voxelotor dose per labeling and monitor hemoglobin response and armodafinil adverse effects.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
