Drug interactions
Armodafinil + Warfarin
Severity: Moderate
Armodafinil and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may modestly alter warfarin exposure, and INR changes have been reported with modafinil-type agents. The effect is variable and usually modest.
What this interaction means in plain words
Armodafinil and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Warfarin belongs to Cardiovascular.
Why it happens
Weak modulation of CYP enzymes (CYP2C19 inhibition and CYP3A4 induction) affecting warfarin enantiomer metabolism.
What to do
Monitor INR more frequently when starting or stopping armodafinil. Adjust the warfarin dose based on results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Warfarin?
MediHelp rates the interaction as moderate. Armodafinil and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may modestly alter warfarin exposure, and INR changes have been reported with modafinil-type agents. The effect is variable and usually modest.
How serious is the interaction between Armodafinil and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently when starting or stopping armodafinil. Adjust the warfarin dose based on results.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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