Drug interactions
Armodafinil + Ziprasidone
Severity: Minor
Armodafinil and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone is sedating and prolongs the QT interval, while armodafinil promotes wakefulness and can increase heart rate. Armodafinil may also reduce ziprasidone exposure slightly via CYP3A4 induction, and the sedative effects oppose each other.
What this interaction means in plain words
Armodafinil and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic CNS effects, with possible weak CYP3A4 induction.
What to do
Monitor alertness, psychiatric symptoms and heart rhythm in patients with QT risk factors. Check an ECG if symptoms such as palpitations or syncope occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Armodafinil with Ziprasidone?
MediHelp rates the interaction as minor. Armodafinil and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ziprasidone is sedating and prolongs the QT interval, while armodafinil promotes wakefulness and can increase heart rate. Armodafinil may also reduce ziprasidone exposure slightly via CYP3A4 induction, and the sedative effects oppose each other.
How serious is the interaction between Armodafinil and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor alertness, psychiatric symptoms and heart rhythm in patients with QT risk factors. Check an ECG if symptoms such as palpitations or syncope occur.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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