Drug interactions
Arsenic trioxide + Benazepril
Severity: Moderate
Arsenic trioxide and Benazepril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arsenic trioxide can cause hypotension, fluid shifts, and electrolyte disturbances, including QT prolongation. Combined with benazepril, blood pressure and renal function may be affected, and electrolyte shifts matter given QT risk.
What this interaction means in plain words
Arsenic trioxide and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arsenic trioxide belongs to Oncology; Benazepril belongs to Cardiovascular.
Why it happens
Additive hypotension and possible volume or electrolyte disturbance with ACE inhibition; mechanism not fully characterized.
What to do
Monitor blood pressure, renal function, potassium and magnesium throughout treatment and correct abnormalities. Adjust benazepril if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Arsenic trioxide and Benazepril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Arsenic trioxide + Clomipramine Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Arsenic trioxide + Fluphenazine Contraindicated
- Arsenic trioxide + Gemifloxacin Contraindicated
Frequently asked questions
Can I take Arsenic trioxide with Benazepril?
MediHelp rates the interaction as moderate. Arsenic trioxide and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Arsenic trioxide can cause hypotension, fluid shifts, and electrolyte disturbances, including QT prolongation. Combined with benazepril, blood pressure and renal function may be affected, and electrolyte shifts matter given QT risk.
How serious is the interaction between Arsenic trioxide and Benazepril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function, potassium and magnesium throughout treatment and correct abnormalities. Adjust benazepril if hypotension occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
