Drug interactions
Asciminib + Carbamazepine
Severity: Moderate
Asciminib and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may lower asciminib levels and reduce its efficacy. Loss of leukemia control is the concern.
What this interaction means in plain words
Asciminib and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asciminib belongs to Oncology; Carbamazepine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increases asciminib metabolism.
What to do
Prefer a non-inducing alternative where possible. If used, monitor BCR-ABL1 transcript levels closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asciminib
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Asciminib with Carbamazepine?
MediHelp rates the interaction as moderate. Asciminib and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may lower asciminib levels and reduce its efficacy. Loss of leukemia control is the concern.
How serious is the interaction between Asciminib and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing alternative where possible. If used, monitor BCR-ABL1 transcript levels closely.
What other medicines interact with Asciminib?
MediHelp also lists interactions of Asciminib with, for example, Clarithromycin, Dihydroergotamine, Ergotamine. The full list is on the Asciminib page.
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