Drug interactions
Asciminib + Itraconazole
Severity: Moderate
Asciminib and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole raises asciminib exposure. Increased levels may raise toxicity risk, particularly at higher doses.
What this interaction means in plain words
Asciminib and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asciminib belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces asciminib metabolism.
What to do
Monitor for adverse effects such as myelosuppression and pancreatitis. Consider reducing the asciminib dose if toxicity occurs, especially at 200 mg twice daily.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asciminib
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Asciminib with Itraconazole?
MediHelp rates the interaction as moderate. Asciminib and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole raises asciminib exposure. Increased levels may raise toxicity risk, particularly at higher doses.
How serious is the interaction between Asciminib and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects such as myelosuppression and pancreatitis. Consider reducing the asciminib dose if toxicity occurs, especially at 200 mg twice daily.
What other medicines interact with Asciminib?
MediHelp also lists interactions of Asciminib with, for example, Clarithromycin, Dihydroergotamine, Ergotamine. The full list is on the Asciminib page.
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